The actor, who also co-hosted the United Kingdom version of French gameshow "Fort Boyard", appeared on "EastEnders" from 1985 to 1989 and returned to the BBC One series from 2003 to 2005.
A statement from his agent said he died on Friday morning after returning to the United Kingdom from Bulgaria to receive medical attention.
His representative said in a statement that Grantham's "ex-wife and sons have asked for their privacy to be respected at this hard time, and for there to be no approaches to them for information or comment".
"They will not be making any statements to the media". His representatives said there would be a private funeral for close friends and family.
Meanwhile, John Yorke, EastEnders' Executive Consultant, said in a statement: "Everyone at EastEnders is deeply saddened to hear that Leslie has passed away".
The actor, best known as rogue "Dirty Den" in the BBC One soap, had been ill and had been receiving treatment in hospital.
Dobson added: "I came from nothing, from the east end with no money, and Leslie, as you know, had a chequered life before EastEnders, but we sort of understood each other, we understood that life can be tough".
Grantham first left Albert Square in 1989 after a criminal gang he was involved with, called The Firm, tried to kill him.
He and Anita [Dobson, who played Sharon's mum Angie] looked after me in my early days and showed me the ropes, always with care and kindness.
The soap's 1986 Christmas Day episode - which saw Den hand over divorce papers to wife Angie - is still one of the most-watched TV episodes ever, with over 30 million viewers.
India vs Afghanistan Test - Day 1 Scorecard
Let's hope that the game is played in great spirits and bring joy to the people of India and Afghanistan . And past year , against Sri Lanka , he smashed 126 runs in the second session of first day in Galle.
Grantham is survived by his ex-wife, Jane Laurie, and three sons.
Leslie was convicted of murder in 1966 and served ten years in prison after a taxi robbery in Berlin went wrong.
His second stint on the show was also marked by controversy, after Grantham was revealed to have conducted webcam sex sessions from his EastEnders dressing room.
Broadcaster Paul Ross remembered him as a "talented, kind and very amusing man", while Craig Fairbrass - who played Dan Sullivan in EastEnders - said he had been "a strong role model".
Fire evacuations lifted in San Juan Co. Wednesday
No homes have yet been lost in the fire, the Associated Press reports, but thousands have been forced to evacuate . Firefighters said Monday that full containment of the 416 Fire was not expected before the end of the month.
Liverpool , the losing Champions League finalists, appear to have the toughest start of any of the likely title-contenders. Sky Sports have ranked all 20 clubs in terms of who has the most hard set of fixtures to open the 2018/19 season.
More than 1.8 million people have entered Europe irregularly since 2014 and Italy is now sheltering some 170,000 asylum seekers. He also said that between January and May, France had sent back to Italy 10,249 migrants who had crossed their common border.
Iceland was indebted to Halldorsson for picking up a point, though, as he kept out Messi's spot-kick shortly after the hour mark. Russian Federation selected 11 host cities to be the venues for the matches of the 2018 World Cup and they are Moscow, St.
He explained that such an attorney does "nothing but make deals with the United States attorney's office". "It certainly could signal an attempt to make a friendly deal with the prosecutor", Dershowitz said .
Phil Mickelson insisted he did not disrespect the sport of golf or the US Open after he putted a moving ball in the third round. Mickelson was penalized two strokes for hitting a moving ball and made a 10 on the hole, on his way to a third-round 81.
At 334,000 inhabitants when they qualified, Iceland are the smallest ever nation to reach the World Cup finals. Argentina only made it to the finals courtesy of a Messi hat-trick in their final qualifier against Ecuador.
They may also discuss efforts to recover the remains of soldiers missing and presumed dead from the 1950-53 Korean War. The Sankei Shimbun said Kim discussed the possibility during historic talks Tuesday with US President Donald Trump .
Two sheriff's deputies were fatally shot when an inmate overpowered them near a Kansas courthouse on Friday , officials said. He also says he doesn't know if the woman had left the shed or was still inside when she was shot.
The driver, who tried to flee the scene, was caught by police, local media has claimed, citing emergency services sources. An ambulance is parked near a damaged taxi, which ran into crowds of people in central Moscow , Russia June 16, 2018.
Not so much for the opponent but to be risky for our opponents, create opportunities and score. This match is one of four on the schedule on Saturday, as Groups C and D roar into life.
Porter Jr. Cancels Workout Over Major Spasms
ESPN's Adrian Wojnarowski notes that Porter's spasms were likely caused by an increased number of workouts after surgery. Porter Jr, now 19 years of age, is a 6-foot-10 forward who's drawn loads of attention from most teams around the league.
Paul Manafort Is Going to Jail
When Manafort was first indicted, the White House said the charges had nothing to do with the president and the 2016 campaign. Manafort was led out of the courtroom by security officers. "It is not about the conduct of the Office of Special Counsel".
Trump ignites trade war with China, triggering swift retaliation
China will "immediately introduce taxation measures of the same scale and the same strength", the Chinese Commerce Ministry said. The moves brought the world's two largest economies to the verge of an all-out confrontation long feared by markets an industry.
Phil Mickelson freestyles hole 13 of US Open Championship
As he walked off the green, he could be seen smiling and talking to playing partner Andrew Johnston, who also was smiling. Mickelson would shoot an 11-over 81 in the third round that dropped him to 17 over for the week and in 65th place.
Woods blames putting for US Open misery
In flawless scoring conditions in the afternoon, no one could catch him. "It's really hard out there", Day told reporters. It trickled over the green and down the slope, and Spieth didn't get back on the green until he played three more shots.
Oprah Winfrey to produce shows for Apple
Companies like Amazon and Netflix have been aggressively pursuing top talent and locking them down with lucrative deals. She is a significant get for Apple , as the host of one of the most-watched daytime shows in America, and her signing.