Trial first to show immunotherapy benefit in prostate cancer

06 June, 2018, 12:50 | Author: Jeffery Armstrong
  • Screen Shot 2018 06 03

A new study conducted by the Institute of cancer research and the Royal Marsden hospital in London has shown unbelievable results in patients with prostate cancer.

The world's leading expert on prostate cancer Professor Johann de Bono from the Institute of cancer research said: "We hope for a revolutionary cure, but they can't call it". These are medications which boost the immune system, and here trials have shown combination treatments to have have saved the lives of some men who were diagnosed with terminal prostate cancer.

"In the last few years immunotherapy has changed the way we treat many advanced cancers - but up to now no one had demonstrated a benefit in men with prostate cancer".

But after taking into account other factors - such as site of the cancer and prostate-specific antigen (PSA) levels - the researchers found that black men had a 19 percent lower risk of dying during the study period than white men. "Every patient who participates in a clinical trial contributes to improving care, and all patients should have the opportunity to receive needed therapies", she said in an American Society of Clinical Oncology (ASCO) news release. Prostate cancer can develop when cells in the prostate start to grow in an uncontrolled way.

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Earlier studies found that black men with advanced prostate cancer who received treatment died sooner than white men, but the evidence has been inconsistent, the researchers noted.

While only 5% of men in the trial saw their tumours shrink or disappear after treatment, many of those had mutations in genes involved in repairing DNA in their tumours.

They stop cancers turning off the immune system so the body can keep on attacking the tumour.

Data from some other cancer types, such as bowel, has similarly shown tumours with defects in DNA fix mutations are more susceptible to immunotherapy.

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"It's exciting that immunotherapy could offer some men more time with their loved ones where they have such advanced disease that they have run out of existing treatment options".

Black men have a 60 percent higher rate of getting prostate cancer.

However, the therapy will not work for most patients. According to the researchers, the immunotherapy treatment with the pembrolizumab is first of its kind to show beneficial effects to such an extent. Most prostate cancers are slow growing; however, some grow very quickly. He added: 'The next stage is to try and develop tests to help us better identify which patients will benefit most'.

International Friendly Report: England v Nigeria 02 June 2018
But after that we dealt with it well. "I thought we used the ball well and were a threat going forward", said Southgate. But, the England manager insisted his player's adjusted to the new formation and were unlucky not to score more goals.

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