Reducing Your Consumption Of These Foods Could Help Fight Breast Cancer

08 February, 2018, 13:17 | Author: Kim Reid
  • Discovery in understanding the spread of breast cancer could lead to new treatments to slow metastasis

At Magee-Womens Research Institute (MWRI) and UPMC Hillman Cancer Center, a large team of clinical and laboratory researchers dedicated to understanding treatment resistance in the most common form of breast cancer have identified a new genetic change in the estrogen receptor (ER) that contributes to therapy resistance.

Asparagine is an amino acid that is made naturally in the body as a building block for proteins.

Scientists have uncovered a key mechanism that facilitates the spread of breast cancer cells, and thus a potential target for new therapeutic approaches in the fight against the disease.

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And when combined with other methods of asparagine limitation, metastasis was reduced by about 20 times, he said.

When the availability of asparagine was reduced, we saw little impact on the primary tumour in the breast, but tumour cells had reduced capacity for metastases (spread) in other parts of the body, the study's lead author, Professor Greg Hannon, said.

The researchers discovered that the appearance of asparagine synthetase-the enzyme cells used to make asparagine-in a primary tumor was strongly associated with later cancer spread. But the researchers are still considering a human trial to see if the diet can really help.

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The initial attack happened eight kilometers, or roughly five miles, east of the de-confliction line on the Euphrates River. The official said they have not ruled out that Iranian backed-forces might have also been involved in the attack.

The researchers, whose study is published in the journal Nature, also found an asparagine link when they examined data from breast cancer patients.

Reference Simon R.V. Knott, Elvin Wagenblast, Showkhin Khan, Sun Y. Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L. Gable, Ashley R. Maceli, Steffen Dickopf, Evangelia K. Papachristou, Clive S. D'Santos, Lisa A. Carey, John E. Wilkinson, J. Chuck Harrell, Charles M. Perou, Hani Goodarzi, George Poulogiannis, Gregory J. Hannon. The same was seen in cancers of the head, neck and kidney.

"This is interesting research looking at how cutting off the supply of nutrients essential to cancer's spread could help restrain tumours". ER-positive breast cancer, diagnosed in two-thirds of breast cancer patients, is fueled by the presence of estrogen in the body. It was more likely to be restricted to one site, potentially making the cancer significantly less harmful.

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"In the future, restricting this amino acid through a controlled diet plan or by other means could be an additional part of treatment for some patients with breast and other cancers".

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